Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 25, Issue 11, Pages 558-566Publisher
CELL PRESS
DOI: 10.1016/j.tem.2014.07.002
Keywords
healthspan; longevity; calorie restriction; fasting mimicking diet (FMD); dietary intervention
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Funding
- NIH/NIA [AG20642, AG025135, P01 AG034906]
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Many of the effects of dietary restriction (DR) on longevity and health span in model organisms have been linked to reduced protein and amino acid (AA) intake and the stimulation of specific nutrient signaling pathways. Studies in yeast have shown that addition of serine, threonine, and valine in media promotes cellular sensitization and aging by activating different but connected pathways. Protein or essential AA restriction extends both lifespan and healthspan in rodent models. In humans, protein restriction (PR) has been associated with reduced cancer, diabetes, and overall mortality. Thus, interventions aimed at lowering the intake of proteins or specific AAs can be beneficial and have the potential to be widely adopted and effective in optimizing healthspan.
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