Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 25, Issue 1, Pages 5-7Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.09.001
Keywords
assisted reproductive technologies; mtDNA mutations
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Funding
- National Institutes of Health [HD063276, HD057121, HD059946, 8P510D011092]
- Leducq Foundation
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R01HD057121, R01HD059946, R01HD063276] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P51OD011092] Funding Source: NIH RePORTER
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Inherited diseases caused by mitochondrial gene (mtDNA) mutations affect at least 1 in 5000-10 000 children and are associated with severe clinical symptoms. Novel reproductive techniques designed to replace mutated mtDNA in oocytes or early embryos have been proposed to prevent transmission of disease from parents to their children. Here we review the efficacy and safety of these approaches and their associated ethical and regulatory issues.
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