Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 24, Issue 9, Pages 460-468Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.04.004
Keywords
nuclear receptors; gene transcription; macrophage; inflammation; lipid metabolism
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Funding
- Spanish Ministry of Economy and Competitiveness [SAF2012-31483]
- European Foundation for the Study of Diabetes-Lilly Fellowship Program
- Spanish Ministry of Science, and Innovation (FPU) [AP2008-00508]
- Spanish Ministry of Economy and Competitiveness
- Pro-CNIC Foundation
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Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism. Recent advances reveal that RXRs are important regulators of macrophages, key players in inflammatory and metabolic disorders. This review outlines the versatility of RXR action in the control of macrophage gene transcription through its heterodimerization with other NRs or through RXR homodimerization. We also highlight the potential of RXR-controlled transcriptional programs as targets for the treatment of pathologies associated with altered macrophage function, such as atherosclerosis, insulin resistance, autoimmunity, and neurodegeneration.
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