Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 24, Issue 7, Pages 342-350Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.01.006
Keywords
lipid transport; intracellular; ABC transporter
Categories
Funding
- United States Public Health Service grant [HL30568]
- Laubisch Fund at UCLA
- American Heart Association Western States [11POST7300060, 11POST7240070]
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Almost half of the 48 human ATP-binding cassette (ABC) transporter proteins are thought to facilitate the ATP-dependent translocation of lipids or lipid-related compounds. Such substrates include cholesterol, plant sterols, bile acids, phospholipids, and sphingolipids. Mutations in a substantial number of the 48 human ABC transporters have been linked to human disease. Indeed the finding that 12 diseases have been associated with abnormal lipid transport and/or homeostasis demonstrates the importance of this family of transporters in cell physiology. This review highlights the role of ABC transporters in lipid transport and movement, in addition to discussing their roles in cellular homeostasis and inherited disorders.
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