Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 24, Issue 9, Pages 442-450Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.05.002
Keywords
brown; beige; adipocyte; microRNA; adipogenesis
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Funding
- UCL starting fund
- National Institutes of Health [DK047618, DK 068348, 5P01 HL066105]
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Brown adipose tissue (BAT) is specialized for heat generation and energy expenditure as a defense against cold and obesity; in both humans and mice increased amounts of BAT are associated with a lean phenotype and resistance to development of the metabolic syndrome and its complications. Here we summarize recent research showing that several BAT-expressed microRNAs (miRNAs) play important roles in regulating differentiation and metabolism of brown and beige adipocytes; we discuss the key mRNA targets downregulated by these miRNAs and show how these miRNAs affect directly or indirectly transcription factors important for BAT development. We suggest that these miRNAs could be part of novel therapeutics to increase BAT in humans.
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