Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 24, Issue 12, Pages 589-596Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2013.08.006
Keywords
angiogenesis; tip cell; branching; filopodia; glycolysis; PFKFB3
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Funding
- Institution of Research and Innovation (IWT)
- Federal Government Belgium [IUAP P7/03]
- Flemish Government
- Belgian Science Fund (FWO)
- European Research Council (ERC) Advanced Research Grant [EU-ERC26907]
- AXA Research Fund
- Foundation Leducq Transatlantic Artemis Network
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Vessel sprouting by endothelial cells (ECs) during angiogenesis relies on a navigating tip cell and on proliferating stalk cells that elongate the shaft. To date, only genetic signals have been shown to regulate vessel sprouting. However, emerging evidence indicates that the angiogenic switch also requires a metabolic switch. Indeed, angiogenic signals not only induce a change in EC metabolism but this metabolic adaptation also co-determines vessel sprouting. The glycolytic activator PFKFB3 regulates stalk cell proliferation and renders ECs more competitive to reach the tip. We discuss the emerging link between angiogenesis and EC metabolism during the various stages of vessel sprouting, focusing only on genetic signals for which an effect on EC metabolism has been documented.
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