Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 23, Issue 7, Pages 319-325Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.03.004
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Funding
- National Institutes of Health [DK077086, HL097738]
- American Diabetes Association
- American Heart Association
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Nutrient and energy metabolism in mammals exhibits a strong diurnal rhythm that aligns with the body clock. Circadian regulation of metabolism is mediated through reciprocal signaling between the clock and metabolic regulatory networks. Recent work has demonstrated that autophagy is rhythmically activated in a clock-dependent manner. Because autophagy is a conserved biological process that contributes to nutrient and cellular homeostasis, its cyclic induction may provide a novel link between clock and metabolism. This review discusses the mechanisms underlying circadian autophagy regulation, the role of rhythmic autophagy in nutrient and energy metabolism, and its implications in physiology and metabolic disease.
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