Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 23, Issue 6, Pages 270-277Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.01.003
Keywords
-
Categories
Funding
- National Institutes of Health [DK51563, DK62876, DK92759]
- Royal Commission for the Exhibition (United Kingdom)
Ask authors/readers for more resources
The past decade has witnessed an explosion in research into adipose tissue stem cells (ASCs), facilitated by their ease of isolation from white adipose tissue (WAT) and fueled by their therapeutic potential. Recent developments have extended ASC multipotency to include endodermal and ectodermal cell types, as well as the generation of induced pluripotent stem cells. This expanding multipotency has been paralleled by burgeoning translational applications, ranging from tissue engineering to anti-cancer therapy, that are currently subject to clinical trials. However, this promise is tempered by potential pitfalls, such as tumorigenicity, and is further undermined by lingering uncertainties regarding the precise identity of ASCs. Confronting these issues will be essential if we are to bypass the pitfalls and develop the promises of ASCs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available