Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 23, Issue 7, Pages 312-318Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.02.003
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Funding
- NIH [F32 DK092034-01, P01AG011412, R01HL097817-01, 1R01DK090625-01A1]
- NIDDK [T32 DK007169]
- American Diabetes Association
- Chicago Biomedical Consortium Searle Funds
- Juvenile Diabetes Research Foundation
- University of Chicago Diabetes Research and Training Center [P60 DK020595]
- Amylin Pharmaceuticals
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The circadian system synchronizes behavioral and physiologic processes with daily changes in the external light-dark cycle, optimizing energetic cycles with the rising and setting of the sun. Molecular clocks are organized hierarchically, with neural clocks orchestrating the daily switch between periods of feeding and fasting, and peripheral clocks generating 24 h oscillations of energy storage and utilization. Recent studies indicate that clocks respond to nutrient signals and that a high-fat diet influences the period of locomotor activity under free-running conditions, a core property of the clock. A major goal is to identify the molecular basis for the reciprocal relation between metabolic and circadian pathways. Here the role of peptidergic hormones and macromolecules as nutrient signals integrating circadian and metabolic systems is highlighted.
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