Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 23, Issue 9, Pages 459-466Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.06.006
Keywords
mitochondria; peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1); peroxisome proliferator-activated receptor (PPAR); transcription; gene regulation; metabolism
Categories
Funding
- National Institutes of Health [R01 DK045416, R01 HL058493, R01 HL101189]
- National Institute of General Medical Sciences [R01 GM32525-28]
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Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial biogenesis and function. Some of these factors act exclusively within the mitochondria to regulate the control of mitochondrial transcription, translation, and other functions. Others govern the expression of nuclear genes required for mitochondrial metabolism and organelle biogenesis. The peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family of transcriptional coactivators play a major role in transducing and integrating physiological signals governing metabolism, differentiation, and cell growth to the transcriptional machinery controlling mitochondrial functional capacity. Thus, the PGC-1 coactivators serve as a central component of the transcriptional regulatory circuitry that coordinately controls the energy-generating functions of mitochondria in accordance with the metabolic demands imposed by changing physiological conditions, senescence, and disease.
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