Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 23, Issue 6, Pages 261-269Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.02.004
Keywords
development; physiology; systems biology
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Funding
- Canadian Institutes of Health Research
- Agence Nationale de la Recherche
- INSERM
- CNRS
- Universities of Montpellier 1 and 2
- National Biophotonics and Imaging Platform (Ireland) (NBIPI)
- Fondation pour la Recherche Medicale
- Reseau National des Genopoles
- Institut Federatif de Recherches
- Region Languedoc Roussillon
- MRC
- Diabetes UK [12/0004431] Funding Source: researchfish
- Medical Research Council [MC_U117562207] Funding Source: researchfish
- MRC [MC_U117562207] Funding Source: UKRI
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Recent advances in tridimensional (3D) tissue imaging have considerably enriched our view of the pituitary gland and its development. Whereas traditional histology of the pituitary anterior lobe portrayed this tissue as a patchwork of cells, 3D imaging revealed that cells of each lineage form extensive and structured homotypic networks. In the adult gland these networks contribute to the robustness and coordination of the cell response to secretagogs. In addition, the network organization adapts to changes in endocrine environment, as revealed by the sexually dimorphic growth hormone (GH) cell network. Further work is required to establish better the molecular basis for homotypic and heterotypic interactions in the pituitary as well as the implications of these interactions for pituitary function and dysfunction in humans.
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