Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 23, Issue 11, Pages 582-590Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2012.05.005
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Funding
- Takayanagi Osteonetwork Project [Exploratory Research for Advanced Technology (ERATO)] from the Japan Science and Technology Agency
- Japan Society for the Promotion of Science (JSPS)
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT)
- Tokyo Biochemical Research Foundation
- Life Science foundation of Japan
- Takeda Science Foundation
- Uehara Memorial Foundation
- Nakatomi Foundation
- Kowa Life Science Foundation
- Naito Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Bristol-Myers K.K. RA Research Fund
- Grants-in-Aid for Scientific Research [24390412] Funding Source: KAKEN
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Bone is continuously renewed through a dynamic balance between bone resorption and formation. This process is the fundamental basis for the maintenance of normal bone mass and architecture. Osteoclasts play a crucial role in both physiological and pathological bone resorption, and receptor activator of nuclear factor-kappa B ligand (RANKL) is the key cytokine that induces osteoclastogenesis. Here we summarize the recent advances in the understanding of osteoclastogenic signaling by focusing on the investigation of RANKL signaling and RANKL-expressing cells in the context of osteoimmunology. The context afforded by osteoimmunology will provide a scientific basis for future therapeutic approaches to diseases related to the skeletal and immune systems.
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