Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 22, Issue 6, Pages 241-248Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2011.03.004
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Funding
- Gladstone Institutes
- Hellman Family Foundation
- NIH [R56 AI085056, P30 DK026743]
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Hepatitis C virus (HCV) infects approximately 3% of the world's population, establishing a lifelong infection in the majority of cases. The life cycle of HCV is closely tied to the lipid metabolism of liver cells, and lipid droplets have emerged as crucial intracellular organelles that support persistent propagation of viral infection. In this review, we examine recent advances in our understanding of how HCV usurps intracellular lipids to propagate, and highlight unique opportunities for therapeutic intervention.
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