Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 22, Issue 2, Pages 74-80Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2010.10.004
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- NIH, NIDDK
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Impaired function of pancreatic beta-cells is one of the hallmarks of type 2 diabetes. beta-cell function is regulated by the activity of many hormones and neurotransmitters, which bind to specific cell surface receptors. The M-3 muscarinic acetylcholine receptor (M3R) belongs to the superfamily of G protein-coupled receptors and, following ligand dependent activation, selectively activates G proteins of the G(q/11) family. Recent studies with M3R mutant mice strongly suggest that beta-cell M3Rs play a central role in promoting insulin release and maintaining correct glucose homeostasis. In this review, we highlight recent studies indicating that beta-cell M3Rs and components of downstream signaling pathways might represent promising new targets for the treatment of type 2 diabetes.
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