Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 22, Issue 11, Pages 437-442Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2011.07.004
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Funding
- National Institute on Aging (NIA)
- Ellison Medical Foundation
- Glenn Foundation for Medical Research
- institutional Geriatrics Research Initiative
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Growth hormone (GH) affects somatic growth, sexual maturation, body composition and metabolism, as well as aging and longevity. Mice lacking GH or GH receptor outlive their normal siblings and exhibit symptoms of delayed aging associated with improved insulin signaling and increased stress resistance. Beneficial effects of eliminating the actions of GH are counterintuitive but conform to the concept of antagonistic pleiotropy. Evolutionary selection for traits promoting early-life fitness and reproductive success could account for post-reproductive deficits. Reciprocal relationships between GH signaling and longevity discovered in mutant mice apply also to normal mice, other mammalian species, and perhaps humans. This review summarizes the present understanding of the multifaceted relationship between somatotropic signaling and mammalian aging.
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