Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 21, Issue 3, Pages 151-158Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2009.11.001
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Funding
- JDRF
- NIDDK [R01-DK055243]
- Beta Cell Biology Consortium
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK055342] Funding Source: NIH RePORTER
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Inadequate beta-cell mass can lead to insulin insufficiency and diabetes. During times of prolonged metabolic demand for insulin, the endocrine pancreas can respond by increasing beta-cell mass, both by increasing cell size and by changing the balance between beta-cell proliferation and apoptosis. In this paper, we review recent advances in our understanding of the mechanisms that control the adaptive expansion of beta-cell mass, focusing on the islet's response to pregnancy, a physiological state of insulin resistance. Functional characterization of factors controlling both beta-cell proliferation and survival might not only lead to the development of successful therapeutic strategies to enhance the response of the beta-cell to increased metabolic loads, but also improve islet transplantation regimens.
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