Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 21, Issue 1, Pages 17-24Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2009.08.003
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Funding
- Office of the Vice President for Research at The University of Georgia (XY)
- NIH [11D050685]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD050685] Funding Source: NIH RePORTER
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Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA(1-5), and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects of vertebrate reproduction. These include ovarian function, spermatogenesis, fertilization, early embryo development, embryo implantation, embryo spacing, decidualization, pregnancy maintenance and parturition. LPA signaling can also have pathological consequences, influencing aspects of endometriosis and ovarian cancer. Here we review recent progress in LPA signaling research relevant to female and male reproduction.
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