Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 20, Issue 6, Pages 280-286Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2009.02.005
Keywords
-
Categories
Funding
- Michael Smith Foundation for Health Research (MSFHR)
- MSFHR
- Natural Sciences and Engineering Research Council
Ask authors/readers for more resources
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have multiple blood glucose-lowering effects. Recent years have seen a surge of interest in understanding the basic physiology and pathophysiology of incretins and in applying this knowledge to the treatment of diabetes and obesity. Considerable gains have been made in elucidating the mechanisms controlling incretin secretion, and there is growing evidence to suggest that incretins might be involved in the rapid reversal of diabetes observed in gastric bypass patients. Here, we review these recent advances and outline the multiple strategies being pursued to exploit the potential therapeutic benefits of GIP and GLP-1.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available