Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 19, Issue 10, Pages 349-355Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2008.08.004
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Funding
- NIH [RO1 DK 67536, RO1 DK 68721]
- Astra Zeneca
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068721, R01DK067536] Funding Source: NIH RePORTER
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Interest in the importance of Wnt signaling in diabetes has risen after identification of the transcription factor TCF7L2, a component of this pathway, as a strong risk factor for type 2 diabetes. Here, we review emerging new evidence that Wnt signaling influences endocrine pancreas development and modulates mature beta-cell functions including insulin secretion, survival and proliferation. Alterations in Wnt signaling might also impact other metabolic tissues involved in the pathogenesis of diabetes, with TCF7L2 proposed to modulate adipogenesis and regulate GLP-1 production. Together, these studies point towards a role for Wnt signaling in the pathogenesis of type 2 diabetes, highlighting the importance of further investigation of this pathway to develop new therapies for this disease.
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