Journal
TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volume 19, Issue 8, Pages 277-284Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tem.2008.07.003
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Funding
- Wellcome Trust
- Swedish Diabetes Association
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, Brazil
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Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.
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