Journal
TRENDS IN COGNITIVE SCIENCES
Volume 16, Issue 1, Pages 81-91Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2011.11.009
Keywords
-
Funding
- Wellcome Trust
- Medical Research Council
- Medical Research Council [G0701497] Funding Source: researchfish
- MRC [G0701497] Funding Source: UKRI
Ask authors/readers for more resources
A key criticism of the main diagnostic tool in psychiatry, the Diagnostic and Statistical Manual of Mental Health Disorders (DSM-IV), is that it lacks a biological footing. In this article, we argue for a biological approach to psychiatry based on 'neurocognitive endophenotypes', whereby changes in behavioural or cognitive processes are associated with discrete deficits in defined neural systems. We focus on the constructs of impulsivity and compulsivity as key examples of the approach and discuss their possible cross-diagnostic significance, applying them to co-morbidities and commonalities across a range of disorders (attention-deficit/hyperactivity disorder, substance dependence, obsessive-compulsive disorder and eating disorders). We argue that this approach has important implications for the future classification of psychiatric disorders, genetics and therapeutics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available