Journal
TRENDS IN COGNITIVE SCIENCES
Volume 14, Issue 5, Pages 216-222Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tics.2010.03.006
Keywords
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Funding
- National Institutes of Health [R01-EY016407, RL1-DA024855, R01-MH05916, P05-NS048328]
- NATIONAL EYE INSTITUTE [R01EY016407] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059216] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P01NS048328] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [RL1DA024855] Funding Source: NIH RePORTER
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Since its first discovery in the prefrontal cortex, persistent activity during the interval between a transient sensory stimulus and a subsequent behavioral response has been identified in many cortical and subcortical areas. Such persistent activity is thought to reflect the maintenance of working memory representations that bridge past events with future contingent plans. Indeed, the term persistent activity is sometimes used interchangeably with working memory. In this review, we argue that persistent activity observed broadly across many cortical and subcortical areas reflects not only working memory maintenance, but also a variety of other cognitive processes, including perceptual and reward-based decision making.
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