Journal
TRENDS IN CELL BIOLOGY
Volume 28, Issue 11, Pages 926-940Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2018.07.005
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Funding
- Institut Pasteur
- INSERM
- INRA
- French National Research Agency (ANR) (ERANET Infect-ERA PROANTILIS) [ANR-13-IFEC-0004-02]
- French Government Investissement d'Avenir program, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' [ANR-10-LABX-62-IBEID]
- European Research Council (ERC) [H2020-ERC-2014-ADG 670823-BacCellEpi]
- Fondation le Roch les Mousquetaires
- Fondation Louis-Jeantet
- International Balzan Prize Fondation
- Rouen University
- iXcore Foundation for Research
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Manipulation of host protein post-translational modifications (PTMs) is used by various pathogens to interfere with host cell functions. Among these modifications, ubiquitin (UBI) and ubiquitin-like proteins (UBLs) constitute key targets because they are regulators of pathways essential for the host cell. In particular, these PTM modifiers control pathways that have been described as crucial for infection such as pathogen entry, replication, propagation, or detection by the host. Although bacterial pathogens lack eucaryotic-like UBI or UBL systems, many of them produce proteins that specifically interfere with these host PTMs during infection. In this review we discuss the different mechanisms used by bacteria to interfere with host UBI and the two UBLs, SUMO and NEDD8.
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