Decision making during interneuron migration in the developing cerebral cortex

Appropriate interneuron migration and distribution is essential for the construction of functional neuronal circuitry and the maintenance of excitatory/inhibitory balance in the brain. Gamma-aminobutyric acid (GABA)ergic interneurons originating from the ventral telencephalon choreograph a complex pattern of migration to reach their target destinations within the developing brain. This review examines the cellular and molecular under pinnings of the major decision-making steps involved in this process of oriental navigation of cortical interneurons.