Journal
TRENDS IN CELL BIOLOGY
Volume 24, Issue 8, Pages 479-487Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.04.001
Keywords
hematopoietic stem cells; blood; quiescence; glycolysis; reactive oxygen species; fatty acid oxidation
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Funding
- NCI NIH HHS [R01 CA184014] Funding Source: Medline
- NHLBI NIH HHS [R01 HL092471, R01 HL111266] Funding Source: Medline
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Hematopoietic stem cells (HSCs) are a rare population of somatic stem cells that maintain blood production and are uniquely wired to adapt to diverse cellular fates during the lifetime of an organism. Recent studies have highlighted a central role for metabolic plasticity in facilitating cell fate transitions and in preserving HSC functionality and survival. This review summarizes our current understanding of the metabolic programs associated with HSC quiescence, self-renewal, and lineage commitment, and highlights the mechanistic underpinnings of these changing bioenergetics programs. It also discusses the therapeutic potential of targeting metabolic drivers in the context of blood malignancies.
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