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LIM proteins in actin cytoskeleton mechanoresponse

Journal

TRENDS IN CELL BIOLOGY
Volume 24, Issue 10, Pages 575-583

Publisher

ELSEVIER SCIENCE LONDON
DOI: 10.1016/J.tcb.2014.04.009

Keywords

mechanotransduction; stress fiber; zyxin; LIM domain; focal adhesion

Categories

Funding

  1. National Institutes of Health [GM50877]
  2. Huntsman Cancer Foundation
  3. National Cancer Institute Cancer Center Support Grant

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The actin cytoskeleton assembles into branched networks or bundles to generate mechanical force for critical cellular processes such as establishment of polarity, adhesion, and migration. Stress fibers (SFs) are contractile actomyosin structures that physically couple to the extracellular matrix through integrin-based focal adhesions (FAs), thereby transmitting force into and across the cell. Recently, LIN-11, Isl1 and MEC-3 (LIM) domain proteins have been implicated in mediating this cytoskeletal mechanotransduction. Among the more well-studied LIM domain adapter proteins is zyxin, a dynamic component of both FAs and SFs. Here we discuss recent research detailing the mechanisms by which SFs adjust their structure and composition to balance mechanical forces and suggest ways that zyxin and other LIM domain proteins mediate mechanoresponse.

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