Journal
TRENDS IN CELL BIOLOGY
Volume 24, Issue 5, Pages 285-293Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.11.009
Keywords
epithelial polarity; adherens junction; E-Cadherin; actin; Myosin II
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Funding
- ANR-MorphoDro
- ARC
- ERC-CePoDro
- CNRS
- INSERM
- Curie Institute
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The study of cytokinesis in single-cell systems provided a wealth of knowledge on the molecular and biophysical mechanisms controlling daughter cell separation. In this review, we outline recent advances in the understanding of cytokinesis in epithelial tissues. These findings provide evidence for how the cytokinetic machinery adapts to a multicellular context and how the cytokinetic machinery is itself exploited by the tissue for the preservation of tissue function and architecture during proliferation. We propose that cytokinesis in epithelia should be viewed as a multicellular process, whereby the biochemical and mechanical interactions between the dividing cell and its neighbors are essential for successful daughter cell separation while defining epithelial tissue organization and preserving tissue integrity.
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