Journal
TRENDS IN CELL BIOLOGY
Volume 24, Issue 3, Pages 179-187Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.09.011
Keywords
induced pluripotent stem cells; small molecules; reprogramming; chemical biology; epigenetics
Categories
Funding
- National Science Foundation Graduate Research Fellowship
- National Institute of General Medical Sciences [P01GM099117]
- Robertson Investigator of The New York Stem Cell Foundation
Ask authors/readers for more resources
Pioneering work over the past years has highlighted the remarkable ability of manipulating cell states through exogenous, mostly transcription factor-induced reprogramming. The use of small molecules and reprogramming by transcription factors share a common history starting with the early AZA and MyoD experiments in fibroblast cells. Recent work shows that a combination of small molecules can replace all of the reprogramming factors and many previous studies have demonstrated their use in enhancing efficiencies or replacing individual factors. Here we provide a brief introduction to reprogramming followed by a detailed review of the major classes of small molecules that have been used to date and what future opportunities can be expected from these.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available