Journal
TRENDS IN CELL BIOLOGY
Volume 24, Issue 12, Pages 761-770Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2014.08.005
Keywords
mitochondrial dynamics; differentiation; cardiomyocyte; heart; hair follicle; DRP1; MFN; OPA1; Notch signaling; Ca2+
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Funding
- Telethon Italy [GGP12162, GPP10005]
- AIRC Italy
- ERC ERMITO
- FP7 CIG CristOpa
- MICR FIRB Automed
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Most, if not all mitochondrial functions, including adenosine-5'-triphosphate (ATP) production and regulation of apoptosis and Ca2+ homeostasis, are inextricably linked to mitochondrial morphology and dynamics, a process controlled by a family of GTP-dependent dynamin related 'mitochondria-shaping' proteins. Mitochondrial fusion and fission directly influence mitochondrial metabolism, apoptotic and necrotic cell death, autophagy, muscular atrophy and cell migration. In this review, we discuss the recent evidence indicating that mitochondrial dynamics influence complex signaling pathways, affect gene expression and define cell differentiation. These findings extend the importance of mitochondria to developmental biology, far beyond their mere bioenergetic role.
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