Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 12, Pages 620-633Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.07.006
Keywords
BH3; caspase; MOMP; phosphorylation; ubiquitination
Categories
Funding
- NCI Career Development Award [R00 CA140948]
- cancer center core grant [P30 CA23108]
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Carcinogenesis is a mechanistically complex and variable process with a plethora of underlying genetic causes. Cancer development comprises a multitude of steps that occur progressively starting with initial driver mutations leading to tumorigenesis and, ultimately, metastasis. During these transitions, cancer cells accumulate a series of genetic alterations that confer on the cells an unwarranted survival and proliferative advantage. During the course of development, however, cancer cells also encounter a physiologically ubiquitous cellular program that aims to eliminate damaged or abnormal cells: apoptosis. Thus, it is essential that cancer cells acquire instruments to circumvent programmed cell death. Here we discuss emerging evidence indicating how cancer cells adopt various strategies to override apoptosis, including amplifying the antiapoptotic machinery, downregulating the proapoptotic program, or both.
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