Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 2, Pages 64-71Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.10.006
Keywords
mitochondria; fission; fusion; dynamin-related GTPase; neurodegeneration
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Funding
- Burroughs-Wellcome Medical Scientist Fund Career Award
- National Institutes of Health [1KO8NS062954-01A1, P30NS069496, GM084015, GM089853]
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It has been only 15 years since studies began on the molecular mechanisms underlying mitochondrial fission and fusion using simple model organisms such as Drosophila, yeast, and Caenorhabditis elegans. Beyond the primary functions of mitochondrial fission and fusion in controlling organelle shape, size, and number, it became clear that these dynamic processes are also critical to regulating cell death, mitophagy, and organelle distribution. Now, studies suggest that prominent changes occur in mitochondrial dynamics in a broad array of neurodegenerative diseases, and there is substantial evidence suggesting a key role in disease pathogenesis because neurons are among the most energy-consuming cell types and have a highly developed cell shape. Here, we review the recent findings on mitochondrial dynamics in neurodegeneration.
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