Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 9, Pages 433-441Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.04.006
Keywords
cytokinesis; abscission; midbody; ESCRT; MITD1; Aurora B
Categories
Funding
- Medical Research Council [G0802777]
- Lister Institute for Preventative Medicine
- EMBO Young Investigator Program
- Wellcome Trust [WT093056MA]
- MRC [G0802777] Funding Source: UKRI
- Medical Research Council [G0802777] Funding Source: researchfish
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Abscission, the final step of cytokinesis, mediates the severing of the membrane tether, or midbody, that connects two daughter cells. It is now recognized that abscission is a complex process requiring tight spatio-temporal regulation of its machinery to ensure equal chromosome segregation and cytoplasm content distribution between daughter cells. Failure to coordinate these events results in genetic damage. Here, we review recent evidence suggesting that proper abscission timing is coordinated by cytoskeletal rearrangements and recruitment of regulators of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery such as CEP55 and MIT-domain-containing protein 1 (MITD1) to the abscission site. Additionally, we discuss the surveillance mechanism known as the Aurora B-mediated abscission checkpoint (No Cut), which prevents genetic damage by ensuring proper abscission delay when chromatin is trapped at the midbody.
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