Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 11, Pages 567-574Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.07.005
Keywords
apoptosis; autophagy; Drosophila; oogenesis; ovary; programmed cell death
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Funding
- NIH [R01 GM060574, R01 GM094452]
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Multiple types of cell death exist including necrosis, apoptosis, and autophagic cell death. The Drosophila ovary provides a valuable model to study the diversity of cell death modalities, and we review recent progress to elucidate these pathways. At least five distinct types of cell death occur in the ovary, and we focus on two that have been studied extensively. Cell death of mid-stage egg chambers occurs through a novel caspase-dependent pathway that involves autophagy and triggers phagocytosis by surrounding somatic epithelial cells. For every egg, 15 germline nurse cells undergo developmental programmed cell death, which occurs independently of most known cell death genes. These forms of cell death are strikingly similar to cell death observed in the germlines of other organisms.
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