Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 10, Pages 511-517Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.05.005
Keywords
transmembrane domains; protein sorting; protein traffic; lipid domains; transmembrane receptors; endomembrane system
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Funding
- Intramural NIH HHS [ZIA HD001607-21] Funding Source: Medline
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The transmembrane domains (TMDs) of integral membrane proteins have emerged as major determinants of intracellular localization and transport in the secretory and endocytic pathways. Unlike sorting signals in cytosolic domains, TMD sorting determinants are not conserved amino acid sequences but physical properties such as the length and hydrophilicity of the transmembrane span. The underlying sorting machinery is still poorly characterized, but several mechanisms have been proposed, including TMD recognition by transmembrane sorting receptors and partitioning into membrane lipid domains. Here we review the nature of TMD sorting determinants and how they may dictate transmembrane protein localization and transport.
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