Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 6, Pages 296-304Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.01.008
Keywords
Golgi; biogenesis; cell cycle; ribbon linking; stacking; membrane budding and fusion
Categories
Funding
- National Institutes of Health [GM087364]
- American Cancer Society [RGS-09-278-01-CSM]
- University Michigan
- China Scholarship Council (CSC)
Ask authors/readers for more resources
The Golgi apparatus is a membranous organelle in the cell that plays essential roles in protein and lipid trafficking, sorting, processing, and modification. Its basic structure is a stack of closely aligned flattened cisternae. In mammalian cells, dozens of Golgi stacks are often laterally linked into a ribbon-like structure. Biogenesis of the Golgi during cell division occurs through a sophisticated disassembly and reassembly process that can be divided into three distinct but cooperative steps, including the deformation and reformation of the Golgi cisternae, stacks, and ribbon. Here, we review our current understanding of the protein machineries that control these three steps in the cycle of mammalian cell division: GRASP65 and GRASP55 in Golgi stack and ribbon formation; ubiquitin and AAA ATPases in postmitotic Golgi membrane fusion; and golgins and cytoskeleton in Golgi ribbon formation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available