Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 7, Pages 336-344Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.03.005
Keywords
growth control; insulin/IGF signaling; ecdysone; organ proportions; Drosophila
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Funding
- CNRS
- INSERM
- ANR
- FRM
- Marie Curie Lifelong Training [252373]
- European Research Council [268813]
- European Research Council (ERC) [268813] Funding Source: European Research Council (ERC)
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In animal species undergoing determinate growth, the making of a full-size adult body requires a series of coordinated growth events culminating in the cessation of growth that precedes sexual maturation. The merger between physiology and genetics now coming to pass in the Drosophila model allows us to decipher these growth events with an unsurpassed level of sophistication. Here, we review several coordination mechanisms that represent fundamental aspects of growth control: adaptation of growth to environmental cues, interorgan coordination, and the coordination of growth with developmental transitions. The view is emerging of an integrated process where organ-autonomous growth is coordinated with both developmental and environmental cues to define final body size.
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