Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 2, Pages 81-89Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.10.008
Keywords
myosin-I; mechanochemistry; light chain-binding domain; motor domain
Categories
Funding
- National Institute of General Medical Sciences (NIGMS) [PO1 GM087253, F32 GM097889]
Ask authors/readers for more resources
Members of the myosin-I family of molecular motors are expressed in many eukaryotes, where they are involved in a multitude of critical processes. Humans express eight distinct members of the myosin-I family, making it the second largest family of myosins expressed in humans. Despite the high degree of sequence conservation in the motor and light chain-binding domains (LCBDs) of these myosins, recent studies have revealed surprising diversity of function and regulation arising from isoform-specific differences in these domains. Here we review the regulation of myosin-I function and localization by the motor and LCBDs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available