Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 12, Pages 593-602Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.08.006
Keywords
stromal microenvironment; senescence; SASP; skin cancer; autophagy
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Funding
- Swiss National Foundation [CRSI33-130576/1, 3100A0-122281/1]
- Oncosuisse [02361-02-2009]
- National Institutes of Health [AR39190]
- Swiss National Science Foundation (SNF) [CRSI33_130576] Funding Source: Swiss National Science Foundation (SNF)
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Multifocal and recurrent epithelial tumors, originating from either dormant or de novo cancer cells, are major causes of morbidity and mortality. The age-dependent increase of cancer incidence has long been assumed to result from the sequential accumulation of cancer-driving or -facilitating mutations with induction of cellular senescence as a protective mechanism. However, recent evidence suggests that the initiation and development of epithelial cancer results from a close interplay with its altered tissue microenvironment, with chronic inflammation, stromal senescence, autophagy, and the activation of cancer-associated fibroblasts (CAFs) playing possible primary roles. We will discuss recent progress in these areas, and highlight how this understanding may be used for devising novel preventive and therapeutic approaches to the epithelial cancer problem.
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