Journal
TRENDS IN CELL BIOLOGY
Volume 23, Issue 11, Pages 575-582Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2013.06.003
Keywords
dynein; kinesin; dynein gear; cooperative forces inside cells; organelle transport; in vivo optical trapping
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Funding
- Wellcome Trust UK [WT079214MA]
- Wellcome Trust Department of Biotechnology Senior Fellowship [IA/S/11/2500255]
- Industrial Research and Consultancy Centre at the Indian Institute of Technology Bombay
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Diverse cellular processes are driven by the collective force from multiple motor proteins. Disease-causing mutations cause aberrant function of motors, but the impact is observed at a cellular level and beyond, therefore necessitating an understanding of cell mechanics at the level of motor molecules. One way to do this is by measuring the force generated by ensembles of motors in vivo at single-motor resolution. This has been possible for microtubule motor teams that transport intracellular organelles, revealing unexpected differences between collective and single-molecule function. Here we review how the biophysical properties of single motors, and differences therein, may translate into collective motor function during organelle transport and perhaps in other processes outside transport.
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