Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 12, Pages 653-661Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.08.004
Keywords
protein design; symmetry; cages; biomaterials; nanomaterials; assembly
Categories
Ask authors/readers for more resources
In nature, many proteins have evolved to have self-complementary shapes. This drives them to assemble into supramolecular structures, sometimes cif great complexity, and often carrying out sophisticated cellular functions. Designing novel proteins that can self-assemble into similarly complex structures is a longstanding goal in bioengineering. New ideas, combined with continually improving computer algorithms, are making it possible to advance on that goal, bringing wide-ranging applications in synthetic biology within reach. Prospective applications range from vaccine design to molecular delivery to bioactive materials. Recent strategies and examples of successfully designed protein cages, layers, and crystals are reviewed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available