Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 8, Pages 429-437Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.05.001
Keywords
nuclear transcription factors; mitochondrial function; apoptosis; STAT3
Categories
Funding
- Office of Research and Development, Medical Research Service, Department of Veteran Affairs
- Pauley Heart Center of Virginia Commonwealth University
- [R01 AI059710-01]
- [R21 AI088487]
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Coordinated responses between the nucleus and mitochondria are essential for the maintenance of homeostasis. For over 15 years, pools of nuclear transcription factors (TFs), such as p53 and nuclear hormone receptors, have been observed in the mitochondria. The contribution of the mitochondrial pool of these TFs to their well-defined biological actions is in some cases clear and in others not well understood. Recently, a small mitochondrial pool of the TF signal transducer and activator of transcription factor 3 (STAT3) was shown to modulate the activity of the electron transport chain (ETC). The mitochondrial function of STAT3 encompasses both its biological actions in the heart as well as its oncogenic effects. This review highlights advances in our understanding of how mitochondrial pools of nuclear TFs may influence the function of this organelle.
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