Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 1, Pages 33-41Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2011.10.004
Keywords
-
Categories
Funding
- NIH/NIGMS [R01GM074212, R01GM055297]
Ask authors/readers for more resources
The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs) comprises three proteins -p21(Cip1/WAF1), p27(Kip1), and p57(Kip2) - that bind and inhibit cyclin CDK complexes, which are key regulators of the cell cycle. CIP/KIP CKIs have additional independent functions in regulating transcription, apoptosis and actin cytoskeletal dynamics. These divergent functions are performed in distinct cellular compartments and contribute to the seemingly contradictory observation that the CKIs can both suppress and promote cancer. Multiple ubiquitin ligases (E3s) direct the proteasome-mediated degradation of p21, p27 and p57. This review analyzes recent data highlighting our current understanding of how distinct E3 pathways regulate subpopulations of the CKIs to control their diverse functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available