Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 5, Pages 241-249Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.02.007
Keywords
-
Categories
Funding
- Agence Nationale de la Recherche [ANR-09-RPDOC-005-01]
- Fondation pour la Recherche Medicale
- Ludwig Institute for Cancer Research
- National Institutes of Health [GM074215]
Ask authors/readers for more resources
The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available