Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 12, Pages 683-691Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.09.004
Keywords
bottom up; programmed assembly; tissue engineering; cell-cell interactions; paracrine signaling
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Funding
- DOD [W81XWH-10-1-1023]
- NSF [DGE-0648991]
- [P50 GM081879]
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The complexity of the human body derives from numerous modular building blocks assembled hierarchically across multiple length scales. These building blocks, spanning sizes ranging from single cells to organs, interact to regulate development and normal organismal function but become disorganized during disease. Here, we review methods for the bottom-up and directed assembly of modular, multicellular, and tissue-like constructs in vitro. These engineered tissues will help refine our understanding of the relationship between form and function in the human body, provide new models for the breakdown in tissue architecture that accompanies disease, and serve as building blocks for the field of regenerative medicine.
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