Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 9, Pages 483-491Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.06.003
Keywords
AAA-ATPase; valosin-containing protein; ubiquitin/proteasome system; chromatin; CDC-48
Categories
Funding
- Swedish Research Council
- Swedish Cancer Society
- Karolinska Institute
- Deutsche Forschungsgemeinschaft (CECAD) [FOR885, SFB635, HO2541/1-1, HO2541/4-1, 2014376]
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The AAA (ATPases associated with various cellular activities) family member Cdc48/p97 is best known for its role in ubiquitin-dependent proteasomal degradation of aberrant endoplasmic reticulum (ER) proteins, a process known as ER-associated degradation (ERAD). However, recent studies have also defined Cdc48/p97 as a central player in various chromatin-associated processes linked to cell cycle progression, DNA replication, transcription, and the DNA damage response. Notwithstanding the apparent differences in location and function, the role of Cdc48/p97 in ubiquitin-dependent extraction from chromatin (UDEC) bears striking similarities with its action in ERAD. Here, we discuss recent data that expand our current model of the role of Cdc48/p97 as a ubiquitin-selective segregase in the nuclear chromatin environment.
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