Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 4, Pages 193-200Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.01.003
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Funding
- Agence Nationale de la Recherche (ANR) [ANR-10PDOC-003-01]
- la Ligue Contre le Cancer [RS11/75-122]
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Predicting cellular behavior is a major challenge in cell and developmental biology. Since the late nineteenth century, empirical rules have been formulated to predict the position and orientation of mitotic cleavage planes in plant and animal cells. Here, we review the history of division plane orientation rules and discuss recent experimental and theoretical studies that refine these rules and provide mechanistic insights into how division can be predicted. We describe why some of these rules may better apply to certain cell types and developmental contexts and discuss how they could be integrated in the future to allow the prediction of division positioning in tissues.
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