Journal
TRENDS IN CELL BIOLOGY
Volume 22, Issue 11, Pages 567-575Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2012.08.003
Keywords
kinesin-8; kinesin-13; kinesin-4; microtubule dynamics; microtubule depolymerase
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Funding
- Howard Hughes Medical Institute
- National Institute of Health [GM61345, GM086610]
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The stereotypical function of kinesin superfamily motors is to transport cargo along microtubules. However, some kinesins also shape the microtubule track by regulating microtubule assembly and disassembly. Recent work has shown that the kinesin-8 family of motors emerge as key regulators of cellular microtubule length. The studied kinesin-8s are highly processive motors that walk towards the microtubule plus-end. Once at plus-ends, they have complex effects on polymer dynamics; kinesin-8s. either destabilize or stabilize microtubules, depending on the context. This review focuses on the mechanisms underlying kinesin-8-microtubule interactions and microtubule length control. We compare and contrast kinesin-8s with the other major microtubule-regulating kinesins (kinesin-4 and kinesin-13), to survey the current understanding of the diverse ways that kinesins control microtubule dynamics.
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