Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 7, Pages 424-431Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2011.03.001
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Funding
- French Community of Belgium
- Actions de Recherche Concertees (ARC)
- Fonds National de la Recherche Scientifique (FNRS) Belgium
- Interuniversity Poles of Attraction initiated by the Belgium State [IUAP P6/40]
- Juvenile Diabetes Research Foundation International (JDRFI) [17-2009-106]
- European Union
- EMBO
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Diabetes is a metabolic disease affecting nearly 300 million individuals worldwide. Both types of diabetes (1 and 2) are characterized by loss of functional pancreatic beta-cell mass causing different degrees of insulin deficiency. The Bcl-2 family has a double-edged effect in diabetes. These proteins are crucial controllers of the mitochondrial pathway of beta-cell apoptosis induced by pro-inflammatory cytokines or lipotoxicity. In parallel, some Bcl-2 members also regulate glucose metabolism and beta-cell function. In this review, we describe the role of Bcl-2 proteins in beta-cell homeostasis and death. We focus on how these proteins interact, their contribution to the crosstalk between endoplasmic reticulum stress and mitochondrial permeabilization, their context-dependent usage following different pro-apoptotic stimuli, and their role in beta-cell physiology.
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