Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 6, Pages 328-335Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2011.03.002
Keywords
-
Categories
Funding
- Max Planck Society
- Deutsche Forschungs Gemeinschaft [NE909/3-1]
- European Commission (EURASNET)
Ask authors/readers for more resources
Most eukaryotic protein-coding transcripts contain introns, which vary in number and position along the transcript body. Intron removal through pre-mRNA splicing is tightly linked to transcription by RNA polymerase II as it translocates along each gene. Here, we review recent evidence that transcription and splicing are functionally coupled. We focus on how RNA polymerase II elongation rates impact splicing through local regulation and transcriptional pausing within genes. Emerging concepts of how splicing-related changes in elongation might be achieved are highlighted. We place the interplay between transcription and splicing in the context of chromatin where nucleosome positioning influences elongation, and histone modifications participate directly in the recruitment of splicing regulators to nascent transcripts.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available