Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 1, Pages 20-28Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.09.006
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Funding
- Medical Research Council [MC_U132670597] Funding Source: Medline
- NIGMS NIH HHS [R01 GM087507-01A1, R01 GM087507] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM087507] Funding Source: NIH RePORTER
- MRC [MC_U132670597] Funding Source: UKRI
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Electrophysiological studies have implicated voltage-gated proton channels in several specific cellular contexts. In neutrophils, they mediate charge compensation that is associated with the oxidative burst of phagocytosis. Molecular characterization of the hydrogen voltage-gated channel 1 (HVCN1) has enabled identification of unanticipated and diverse functions: HVCN1 not only modulates signaling from the B-cell receptor following B-cell activation and histamine release from basophils, but also mediates pH-dependent activation of spermatozoa, as well as acid secretion by tracheal epithelium. The importance of HVCN1 in pH regulation during phagocytosis was established by surprising evidence that indicated its first-responder role. In this review, we discuss recent findings from a functional perspective, and the potential of HVCN1 as a therapeutic target for autoimmune and other diseases.
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